Assignment of dioxin-inducible cytochrome P-450 gene family to Chinese hamster chromosome 4.

نویسندگان

  • C E Hildebrand
  • R L Stallings
  • F J Gonzalez
  • D W Nebert
چکیده

The 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P-450 gene family (P1-450 and P3-450 in the C57BL/6N mouse) has recently been localized to mouse chromosome 9. In the present study, HindIII-digested DNA from Chinese hamster, mouse, and 20 Chinese hamster X mouse somatic cell hybrids and subclones segregating hamster chromosomes was probed with the mouse P1-450 and P3-450 full-length cDNA clones. Hamster P-450 gene fragments (6.0 and 7.4 kb) were assigned to Chinese hamster chromosome 4. These data are consistent with linkage conservation among these two P-450 sequences and four other loci on mouse chromosome 9 that map to hamster chromosome 4.

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عنوان ژورنال:
  • Somatic cell and molecular genetics

دوره 11 4  شماره 

صفحات  -

تاریخ انتشار 1985